PR 5C5 is useful for histological diagnosis of colon disorders and has wide reactivity with bowel, small intestine, stomach and colo-rectal tumours.
| Inventor | Institute |
|---|---|
| Walter Bodmer | University of Oxford |
| Cat. #: | 151501 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology;Tissue-specific biology |
| Application: | ELISA ; IHC |
| Target: | Lewis A antigen |
| Reactivity: | Human |
| Clone: | PR 5C5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | PR 5C5 is useful for histological diagnosis of colon disorders and has wide reactivity with bowel, small intestine, stomach and colo-rectal tumours. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Mucosal scrapings and membrane preparations from normal colorectal epithelium and possibly booster inoculations with the colon carcinoma cell line HT29. |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Lewis a antigen is expressed on colonic mucus, epithelial cells and cell membranes. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Richman et al. 1987. Int J Cancer. 39(3):317-28. PMID: 2434440. Monoclonal antibodies to human colorectal epithelium: markers for differentiation and tumour characterization. |
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