Lamin B Receptor (LBR) is a polytopic inner nuclear membrane protein. Its nucleoplasmic domain interacts with components of the nuclear lamina as well as with chromatin, via HP1. LBR also exhibits C14 sterol reductase activity. Deficiency of LBR in humans results in Pelget-Hu??t anomaly featuring hypolobulated granulocyte nuclei. Homozygous loss of LBR causes Greenberg skeletal […]
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| A*STAR Accelerate Technologies Pte Ltd |
| Cat. #: | 153492 |
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| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | IHC; IF ; WB |
| Target: | Lamin B receptor |
| Reactivity: | Human ; Mouse |
| Clone: | BB2SS3F3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | DHCR 14B antibody, DHCR14B antibody, Integral nuclear envelope inner membrane protein antibody, Lamin-B receptor antibody, LBR antibody, LBR_HUMAN antibody, LMN 2R antibody, LMN2R antibody, MGC941 antibody, PHA antibody, PRO65 antibody |
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| Product description: | Lamin B Receptor (LBR) is a polytopic inner nuclear membrane protein. Its nucleoplasmic domain interacts with components of the nuclear lamina as well as with chromatin, via HP1. LBR also exhibits C14 sterol reductase activity. Deficiency of LBR in humans results in Pelger-Huët anomaly featuring hypolobulated granulocyte nuclei. Homozygous loss of LBR causes Greenberg skeletal dysplasia a fetal lethal disorder associated with defective cholesterol metabolism. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | GST fused to N-terminal fragment of human LBR (amino acids residues 1-211) |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Lamin B Receptor (LBR) is a polytopic inner nuclear membrane protein. Its nucleoplasmic domain interacts with components of the nuclear lamina as well as with chromatin, via HP1. LBR also exhibits C14 sterol reductase activity. Deficiency of LBR in humans results in Pelger-Huët anomaly featuring hypolobulated granulocyte nuclei. Homozygous loss of LBR causes Greenberg skeletal dysplasia a fetal lethal disorder associated with defective cholesterol metabolism. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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| 151025 | Anti-Vascular endothelium [10] |
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| 151029 | Anti-HSVICP8 [11E2] |
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| 151034 | Anti-HSVUL42 [13D11] |
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| 151035 | Anti-CD8 [14] mAb |
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| 151040 | Anti-CD11 & CD18 [24] |
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