Kidins220/ARMS (Kinase D-Interacting Substrate of 220 kDa, ARMS; Ankyrin Repeat-rich Membrane Spanning) is an integral membrane protein that is selectively expressed in brain and neuroendocrine cells and phosphorylated by PKD (protein Kinase D). Kidins220 has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases.
| Inventor | Institute |
|---|---|
| Giampietro Schiavo | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151252 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Neurobiology;Tissue-specific biology |
| Application: | ELISA ; IHC ; IP ; WB |
| Target: | Kidins220/ARMS |
| Reactivity: | Rat |
| Clone: | p220 1F8/3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Kidins220/ARMS (Kinase D-Interacting Substrate of 220 kDa, ARMS; Ankyrin Repeat-rich Membrane Spanning) is an integral membrane protein that is selectively expressed in brain and neuroendocrine cells and phosphorylated by PKD (protein Kinase D). Kidins220 has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 220 kDa |
| Immunogen: | Recombinant GST-Kidins220/ARMS (last 347 amino acids at the carboxy terminus) fusion protein. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Kidins220/ARMS (Kinase D-Interacting Substrate of 220 kDa, ARMS; Ankyrin Repeat-rich Membrane Spanning) is an integral membrane protein that is selectively expressed in brain and neuroendocrine cells and phosphorylated by PKD (protein Kinase D). Kidins220 has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Deswal et al. 2013. J Immunol. 190(5):1927-35. PMID: 23359496. Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells. Bracale et al. 2007. Mol Biol Cell. 18(1):142-52. PMID: 17079733. Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation. Iglesias et al. 2000. J Biol Chem. 275(51):40048-56. PMID: 10998417. Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D. |
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