Anti-Keratin7,13,17 & 18 [LdS 23]

LdS 23 is useful for studies of epithelial cells and tumour origin.

Contributors

Inventor Institute
Gisele Hodges Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151114
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: IHC ; IF ; IP ; WB
Target: Keratin 7,13,17 & 18
Reactivity: Human
Clone: LdS 23
Host: Mouse
Class: Monoclonal
Product description: LdS 23 is useful for studies of epithelial cells and tumour origin.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Cytoskeletons of the human urothelial RT4 cell line
Myeloma used: Sp2/0-Ag14
Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. Keratin 17 is expressed in suprabasal keratinocytes of wounded epidermis. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Trejdosiewicz et al. 1986. Exp Cell Res. 164(2):388-98. PMID: 2423348.

Phenotypic analysis of cultured melanoma cells. Expression of cytokeratin-type intermediate filaments by the M5 human melanoma cell line.

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