Cat. #151115
Anti-Keratin10 [LH2]
Cat. #: 151115
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Keratin 10
Class: Monoclonal
Application: FACS ; IHC ; IF ; IP ; WB
Reactivity: Human ; Mouse
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Irene Leigh
Institute: Queen Mary University of London
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-Keratin10 [LH2]
- Alternate name: BCIE, BIE, EHK, Keratin Type I Cytoskeletal 1, KRT1Human Entrez Gene ID 3858 Human SwissProt P13645 Human Unigene 99936 Human Gene Symbol KRT1Human Chromosome Location 17q21.2
- Research fields: Cell signaling and signal transduction
- Clone: LH2
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Molecular weight: 56.5kDa
- Strain: Balb/c
- Reactivity: Human ; Mouse
- Host: Mouse
- Application: FACS ; IHC ; IF ; IP ; WB
- Description: LH2 recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10).
- Immunogen: extract of skin from psoriasis patient
- Isotype: IgG1 kappa
- Myeloma used: Sp2/0-Ag14
- Recommended controls: Extract of skin from psoriasis patient
Target Details
- Target: Keratin 10
- Molecular weight: 56.5kDa
- Tissue cell line specificity: Mouse
- Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 10 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Keratin 10 is a suprabasal marker of differentiation in stratified squamous epith...
Applications
- Application: FACS ; IHC ; IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Lehman et al. 2015. Am J Pathol. 185(1):240-51. PMID: 25529795.
- Barrott et al. 2011. Proc Natl Acad Sci U S A. 108(31):12752-7. PMID: 21768372.
- Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.
- Porter et al. 2000. Lab Invest. 80(11):1701-10. PMID: 11092530.
- K15 expression implies lateral differentiation within stratified epithelial basal cells.
- Reichelt et al. 1997. J Cell Sci. 110 ( Pt 18):2175-86...
