Very good marker for suprabasal keratinocytes.
| Inventor | Institute |
|---|---|
| Nick Tidman | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151903 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | IHC ; WB |
| Target: | Keratin 1 |
| Reactivity: | Human |
| Clone: | LHK1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Reactivity on normal human skin sections is suprabasal up to the tratum corneum in interfollicular epidermis. The suprabasal in the upper outer root sheath are also reactive. Very good marker for suprabasal keratinocytes. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2a kappa |
| Molecular weight: | 68 kDa |
| Immunogen: | 13-amino acid (1 .75-kd) sequence (VRFVSTSYSGVTR) of the K1 polypeptide C terminus |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Reactivity on normal human skin sections is suprabasal up to the tratum corneum in interfollicular epidermis. The suprabasal in the upper outer root sheath are also reactive. Very good marker for suprabasal keratinocytes. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Bloor et al. 2003. Am J Pathol. 162(3):963-75. PMID: 12598329. Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization. Waseem et al. 1999. J Invest Dermatol. 112(3):362-9. PMID: 10084315. Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes. Machesney et al. 1998. Am J Pathol. 152(5):1133-41. PMID: 9588880. Activated keratinocytes in the epidermis of hypertrophic scars. Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603. Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation. |
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