Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Loss of integrin beta 1 is […]
| Institute |
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| Queen Mary University of London |
| Cat. #: | 151222 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Developmental biology;Drug development;Stem cell biology |
| Application: | FACS ; IHC ; IF ; IP ; Fn |
| Target: | Integrin ?1 (CD29) |
| Reactivity: | Human |
| Clone: | 4B7 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Marshall et al. 1998. Br J Cancer. 77(4):522-9. PMID: 9484806. |
| Product description: | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Loss of integrin beta 1 is associated with the development of some epithelial tumours. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Ocular melanoma cell line V+B2 |
| Target background: | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Loss of integrin beta 1 is associated with the development of some epithelial tumours. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Marshall et al. 1998. Br J Cancer. 77(4):522-9. PMID: 9484806. Comparative analysis of integrins in vitro and in vivo in uveal and cutaneous melanomas. |
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