Anti-HIP1r [1E1]

Hybridoma cell line producing the monoclonal antibody, Huntingtin-interacting protein 1-related clone 1E1 (HIP1r [1E1]), the only known mammalian relative of HIP1. HIP1 interacts with huntingtin, the protein whose gene is mutated in Huntington’s disease and has been shown to transform fibroblasts via undefined mechanisms. Studies by Hyun and colleagues (PMID: 14732715) have shown that HIP1 and HIP1R share a Fn homology via binding to 3-phosphorylated inositol lipids and stabilizing receptor tyrosine kinases that may contribute to their overall ability to alter cell growth and survival. The inhibition of HIP1 and HIP1R activity have been shown to interfere with the function…

Contributors

Inventor Institute
Theodora Ross ; Teresa Hyun University of Michigan
Cat. #: 160649
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Developmental biology;Neurobiology
Application: ELISA ; IF ; WB
Target: HIP1r
Host: Mouse
Class: Monoclonal
Alternate name: Huntingtin-interacting protein 1-related clone 1E1
Product description: Hybridoma cell line producing the monoclonal antibody, Huntingtin-interacting protein 1-related clone 1E1 (HIP1r [1E1]), the only known mammalian relative of HIP1. HIP1 interacts with huntingtin, the protein whose gene is mutated in Huntington's disease and has been shown to transform fibroblasts via undefined mechanisms. Studies by Hyun and colleagues (PMID: 14732715) have shown that HIP1 and HIP1R share a functional homology via binding to 3-phosphorylated inositol lipids and stabilizing receptor tyrosine kinases that may contribute to their overall ability to alter cell growth and survival. The inhibition of HIP1 and HIP1R activity have been shown to interfere with the function of multiple growth factor receptors in tumors. HIP1 and HIP1r have also been shown to stabilize growth factor receptor levels via altered intracellular trafficking and have been suggested to play a critical role in the regulation of endocytosis via association with clathrin coats (PMID: 11604514).
Conjugation: Unconjugated
Immunogen: pGEX-HIP1r/TH
Target background: Hybridoma cell line producing the monoclonal antibody, Huntingtin-interacting protein 1-related clone 1E1 (HIP1r [1E1]), the only known mammalian relative of HIP1. HIP1 interacts with huntingtin, the protein whose gene is mutated in Huntington's disease and has been shown to transform fibroblasts via undefined mechanisms. Studies by Hyun and colleagues (PMID: 14732715) have shown that HIP1 and HIP1R share a Fn homology via binding to 3-phosphorylated inositol lipids and stabilizing receptor tyrosine kinases that may contribute to their overall ability to alter cell growth and survival. The inhibition of HIP1 and HIP1R activity have been shown to interfere with the function of multiple growth factor receptors in tumors. HIP1 and HIP1r have also been shown to stabilize growth factor receptor levels via altered intracellular trafficking and have been suggested to play a critical role in the regulation of endocytosis via association with clathrin coats (PMID: 11604514).
Format: Liquid
Shipping conditions: Dry ice
References:

Hyun et al. 2004. J Biol Chem. 279(14):14294-306. PMID: 14732715.

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