Cat. #153203
Anti-Factor VIII:c heavy chain [RFF-VIII:c/10]
Cat. #: 153203
Unit size: 100 ug
Availability: 3-5 days
Target: Factor VIII:c heavy chain
Class: Monoclonal
Application: IF ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Alison Goodall
Institute: University College London (UCL)
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Factor VIII:c heavy chain [RFF-VIII:c/10]
- Research fields: Tissue-specific biology
- Clone: RFF-VIII:c/10
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IF ; WB
- Description: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa.
- Immunogen: Purified human factor VIII
- Isotype: IgG1 kappa
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Factor VIII:c heavy chain
- Target background: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa.
Applications
- Application: IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: RPMI + 10% FCS; non-adherent; subculture every 2-3 days; split 1:5
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-Factor VIII:c light chain [RFF-VIII:c/5] ; Anti-Factor VIII [RFF-VIII:c/8]
References
- Goodall AH et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279 Rotblat F et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638 Rotblat F et al. 1985. Biochemistry. 24: 4294-300. PMID: 2413885
