Anti-Factor VIII:c heavy chain [RFF-VIII:c/10]

The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa.

Contributors

Inventor Institute
Alison Goodall University College London (UCL)
Cat. #: 153203
Unit size: 100 ug
Research Fields: Tissue-specific biology
Application: IF ; WB
Target: Factor VIII:c heavy chain
Reactivity: Human
Clone: RFF-VIII:c/10
Host: Mouse
Class: Monoclonal
Product description: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Purified human factor VIII
Myeloma used: P3/NS1/1-Ag4.1
Target background: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: RPMI + 10% FCS; non-adherent; subculture every 2-3 days; split 1:5
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Goodall AH et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279 Rotblat F et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638 Rotblat F et al. 1985. Biochemistry. 24: 4294-300. PMID: 2413885

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