Factor VII is a 50kDa multi-domain, single chain plasma glycoprotein synthesised in the liver. It is essential for blood coagulation. Factor VII is converted to the active, two chain, serine protease Factor VIIa via cleavage by thrombin, factor Xa, factor IXa or factor XIIa. Factor VIIa converts factor X to factor Xa, which in turn […]
| Inventor | Institute |
|---|---|
| Alison Goodall | University College London (UCL) |
| Cat. #: | 151533 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Tissue-specific biology |
| Application: | ELISA ; Fn ; WB |
| Target: | Factor VII |
| Reactivity: | Human |
| Clone: | RFF-VII/1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Factor VII is a 50kDa multi-domain, single chain plasma glycoprotein synthesised in the liver. It is essential for blood coagulation. Factor VII is converted to the active, two chain, serine protease Factor VIIa via cleavage by thrombin, factor Xa, factor IXa or factor XIIa. Factor VIIa converts factor X to factor Xa, which in turn converts prothrombin to thrombin. This monoclonal antibody partially inhibits human Factor VII activity. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Purified human factor VII |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Factor VII is a 50kDa multi-domain, single chain plasma glycoprotein synthesised in the liver. It is essential for blood coagulation. Factor VII is converted to the active, two chain, serine protease Factor VIIa via cleavage by thrombin, factor Xa, factor IXa or factor XIIa. Factor VIIa converts factor X to factor Xa, which in turn converts prothrombin to thrombin. This monoclonal antibody partially inhibits human Factor VII activity. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Takase et al. 1988. J Clin Pathol. 41(3):342-5. PMID: 3360958. Takase et al. 1988. J Clin Pathol. 41(3):337-41. PMID: 3360957. Monoclonal antibodies to human factor VII: production of immunodepleted plasma for VII:C assays. Monoclonal antibodies to human factor VII: a one step immunoradiometric assay for VII:Ag. |
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