#153631

Anti-Estrogen Receptor Beta1 [PPG5/10]

Cat. #153631

Anti-Estrogen Receptor Beta1 [PPG5/10]

Cat. #: 153631

Sub-type: Primary antibody

Unit size: 100 ug

Target: Estrogen Receptor ?1

Class: Monoclonal

Application: IHC ; IF ; WB

Reactivity: Human ; Pig ; Primate ; Rat ; Sheep ; Rhesus macaque ; Cynomolgus monkey ; Turtle ; Goose

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Institute: BioServ UK Ltd

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Estrogen Receptor Beta1 [PPG5/10]
  • Alternate name: Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2
  • Cancer: Breast cancer;Gynaecologic cancer
  • Cancers detailed: Breast cancer;Broadly Applicable;Ovarian
  • Research fields: Cancer;Immunology;Neurobiology
  • Clone: PPG5/10
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 59 kDa
  • Strain: Balb/c
  • Reactivity: Human ; Pig ; Primate ; Rat ; Sheep ; Rhesus macaque ; Cynomolgus monkey ; Turtle ; Goose
  • Host: Mouse
  • Application: IHC ; IF ; WB
  • Description: Estrogen receptors are commonly over-expressed in cancers. Clone PPG5/10 recognizes Estrogen Receptor Beta (ERÎ?) 1 and is useful in determining the expression of ERÎ?1 in cancer cells, mainly via immunohistochemistry.
  • Immunogen: Synthetic peptide CEDSKSKEGSQNPQSQ derived from the C terminus of human ER?1
  • Isotype: IgG2a
  • Myeloma used: Sp2/0-Ag14
  • Recommended controls: Ovary

Target Details

  • Target: Estrogen Receptor ?1
  • Molecular weight: 59 kDa
  • Tissue cell line specificity: Ovary
  • Target background: Estrogen receptors are commonly over-expressed in cancers. Clone PPG5/10 recognizes Estrogen Receptor Beta (ER?) 1 and is useful in determining the expression of ER?1 in cancer cells, mainly via immunohistochemistry.

Applications

  • Application: IHC ; IF ; WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Shipping conditions: Shipping at 4° C

References

  • Zannoni et al. 2016. Histopathology. 68(4):541-8. PMID: 26132417.
  • Sexual dimorphism in medulloblastoma features.
  • Gender effect in experimental models of human medulloblastoma: does the estrogen receptor ? signaling play a role?
  • Ciucci et al. 2014. PLoS One. 9(7):e101623. PMID: 25000562.
  • Asgari et al. 2011. Diagn Pathol. 6:61. PMID: 21733187.
  • Estrogen receptor beta expression in prostate adenocarcinoma.
  • Collins et al. 2009. BMC Cancer. 9:330. PMID: 19758455.
  • Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha.
  • Schiessl et al. 2005. J Histochem Cytochem. 53(12):1441-9. PMID: 15983116.
  • Wong et al. 2005. J Pathol. 207(1):53-60. PMID: 15954165.
  • ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates.
  • Expression of endothelial NO synthase, inducible NO synthase, and estrogen receptors alpha and beta in placental tissue of normal, preeclamptic, and intrauterine growth-restricted pregnancies.
  • Sierens et al. 2004. J Mol Endocrinol. 32(3):703-18. PMID: 15171710.
  • Cloning of oestrogen receptor beta from Old and New World primates: identification of splice variants and Fn analysis.
  • Torlakovic et al. 2002. Hum Pathol. 33(6):646-51. PMID: 12152165.
  • Prostate carcinoma expression of estrogen receptor-beta as detected by PPG5/10 antibody has positive association with primary Gleason grade and Gleason score.