EME1 (aka Msm4) and Mus81 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes.
| Inventor | Institute |
|---|---|
| Stephen West | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151294 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Developmental biology;Stem cell biology |
| Application: | WB |
| Target: | Essential meiotic endonuclease 1 (EME1) |
| Reactivity: | Human |
| Clone: | MTA31 7h2/1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | EME1 (aka Msm4) and Mus81 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 60-65 kDa |
| Immunogen: | Human EME1 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | EME1 (aka Msm4) and Mus81 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Rass et al. 2010. Genes Dev. 24(14):1559-69. PMID: 20634321. Mechanism of Holliday junction resolution by the human GEN1 protein. Tomoda et al. 2009. Int J Cancer. 124(12):2997-3001. PMID: 19267403. Fn evidence for Eme1 as a marker of cisplatin resistance. |
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