May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
| Inventor | Institute |
|---|---|
| Stephen West | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 152936 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | IHC ; IP ; WB |
| Target: | hDMC1. Human equivalent of E.Coli recA |
| Reactivity: | Human |
| Clone: | 5B10/2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Disrupted meiotic cDNA 1 homolog, Disrupted meiotic cDNA 1, yeast homolog of, dJ199H16.1, DMC 1, DMC1, DMC1 dosage suppressor of mck1 homolog, DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast), DMC1 homologue |
|---|---|
| Product description: | May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Recombinant fusion protein (Human). DMC1 protein (expressed as 6xHis fusion in E. coli and band cut out of gel of insoluble pellet). |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567. The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51. |
|---|
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