Anti-Cytochrome P450 4V2 [M29-P3B10]

Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4V2 catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, […]

Contributors

Inventor Institute
Ayham Alnabulsi Vertebrate Antibodies Limited
Cat. #: 152159
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology
Application: ELISA ; IHC ; WB
Target: Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2)
Reactivity: Human
Clone: M29-P3B10
Host: Mouse
Class: Monoclonal
Alternate name: Cytochrome P45; Family 4; Subfamily V; Polypeptide 2; Docosahexaenoic Acid Omega-Hydroxylase CYP4V2; CYP4AH1; BCD
Product description: Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4V2 catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. CYP4V2 may have a role in fatty acid and steroid metabolism in the eye and its mutations are associated with Bietti's crystalline dystrophy (BCD) and retinitis pigmentosas.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Peptide sequence KREELGLEGQ (amino acids 495 504)
Myeloma used: P3X63Ag8.653
Target background: Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4V2 catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. CYP4V2 may have a role in fatty acid and steroid metabolism in the eye and its mutations are associated with Bietti's crystalline dystrophy (BCD) and retinitis pigmentosas.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Alnabulsi et al. 2017. Br J Cancer. :. PMID: 28557975.

The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.

Alnabulsi et al. 2016. Characterisation of Arachidonic Acid Metabolising Enzymes in Colorectal Cancer. J Pathol. 240 Suppl 1:S1-S48. PMID: 27747872

Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June – 1 July 2016.

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