The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.
| Inventor | Institute |
|---|---|
| Roland Wolf | University of Dundee |
| Cat. #: | 151141 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Tissue-specific biology;Cell signaling and signal transduction;Metabolism |
| Application: | ELISA ; FACS ; WB |
| Target: | Cytochrome P450 3A1, CYP3A1 |
| Reactivity: | Human ; Mouse ; Rat |
| Clone: | P6 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 150-160 kDa |
| Immunogen: | Rat liver cytochrome P450 3A1 |
| Immunogen Uniprot ID: | P06756 |
| Target background: | The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Probert et al. 2014. Toxicol Sci. 137(2):350-70. PMID: 24235770. Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies. Hu et al. 2011. Drug Metab Dispos. 39(3):419-25. PMID: 21135265. Opposite effect of diabetes mellitus induced by streptozotocin on oral and intravenous pharmacokinetics of verapamil in rats. Matuskova et al. 2009. Neuro Endocrinol Lett. 30 Suppl 1:41-5. PMID: 20027143. Influence of probiotics on rat liver biotransformation enzymes. |
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