Anti-CYP450 Aromatase [H4]

Clone H4 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods.

Contributors

Institute
BioServ UK Ltd
Cat. #: 153638
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: IHC ; IF ; WB
Target: CYP450 Aromatase
Reactivity: Human
Clone: H4
Host: Mouse
Class: Monoclonal
Alternate name: Aromatase, CYPXIX, Cytochrome P-45AROM, Cytochrome P45 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19
Product description: CYP450 Aromatase is part of the CYP19A1 family involved in the aromatization of androgens to estrogens, a highly conserved mechanism amongst mammals. Clone H4 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods.
Conjugation: Unconjugated
Isotype: IgG2a
Molecular weight: 55 kDa
Immunogen: Synthetic peptide corresponding to AAs 376-390 of human aromatase (KALEDDVIGYPVKK)
Myeloma used: Sp2/0-Ag14
Target background: CYP450 Aromatase is part of the CYP19A1 family involved in the aromatization of androgens to estrogens, a highly conserved mechanism amongst mammals. Clone H4 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods.
Format: Liquid
Shipping conditions: Dry ice
References:

Amanatullah et al. 2017. Breast Cancer Res. 19(1):121. PMID: 29141657.

Local estrogen axis in the human bone microenvironment regulates estrogenreceptor-positivebreast cancer cells.

Wilsher et al. 2013. Reproduction. 145(6):541-54. PMID: 23550169.

Ovarian and placental morphology and endocrine functions in the pregnant giraffe (Giraffa camelopardalis).

Campbell et al. 2012. Endocrinology. 153(9):4533-43. PMID: 22778215.

The role of anti-Mllerian hormone (AMH) during follicle development in a monovulatory species (sheep).

Mlodawska et al. 2010. Theriogenology. 74(9):1707-12. PMID: 20932560.

Immunohistochemical localization of aromatase during the development and atresia of ovarian follicles in prepubertal horses.

Catalano et al. 2010. J Biol Chem. 285(8):5581-93. PMID: 20026603.

Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.

Sirianni et al. 2009. J Biol Chem. 284(42):28905-16. PMID: 19679653.

Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells.

Rago et al. 2007. Reprod Biol Endocrinol. 5:23. PMID: 17553131.

Cytochrome P450arom, androgen and estrogen receptors in pig sperm.

Rago et al. 2005. Reprod Biol Endocrinol. 3:72. PMID: 16372909.

Cytochrome P450 aromatase expression in human seminoma.

Pakarainen et al. 2005. Mol Endocrinol. 19(10):2591-602. PMID: 15941853.

Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles.

Fazleabas et al. 2003. Fertil Steril. 80 Suppl 2:820-7. PMID: 14505759.

Steroid receptor and aromatase expression in baboon endometriotic lesions.

Turner et al. 2002. J Endocrinol. 172(1):21-30. PMID: 11786371.

Development and validation of a new monoclonal antibody to mammalian aromatase.

Images

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Clone H4 used to detect aromatase in pig sperm by Immunofluorescence. ...B) P450arom red brilliant light in the proximal tail of sperm with a diffuse labelling in the distal tail. Source

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