Anti-CYP450 Aromatase [H4]

Clone H4 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods.

Contributors

Institute
BioServ UK Ltd
SKU: 153638
Product description: CYP450 Aromatase is part of the CYP19A1 family involved in the aromatization of androgens to estrogens, a highly conserved mechanism amongst mammals. Clone H4 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods.
Alternate name: Aromatase, CYPXIX, Cytochrome P-45AROM, Cytochrome P45 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19
Conjugation: Unconjugated
Isotype: IgG2a
Molecular weight: 55 kDa
Immunogen: Synthetic peptide corresponding to AAs 376-390 of human aromatase (KALEDDVIGYPVKK)
Myeloma used: Sp2/0-Ag14
Cat. #: 153638
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: IHC ; IF ; WB
Target: CYP450 Aromatase
Reactivity: Human
Clone: H4
Host: Mouse
Class: Monoclonal
Target background: CYP450 Aromatase is part of the CYP19A1 family involved in the aromatization of androgens to estrogens, a highly conserved mechanism amongst mammals. Clone H4 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods.
Format: Liquid
Shipping conditions: Dry ice
References:

Amanatullah et al. 2017. Breast Cancer Res. 19(1):121. PMID: 29141657.

Local estrogen axis in the human bone microenvironment regulates estrogenreceptor-positivebreast cancer cells.

Wilsher et al. 2013. Reproduction. 145(6):541-54. PMID: 23550169.

Ovarian and placental morphology and endocrine functions in the pregnant giraffe (Giraffa camelopardalis).

Campbell et al. 2012. Endocrinology. 153(9):4533-43. PMID: 22778215.

The role of anti-Mllerian hormone (AMH) during follicle development in a monovulatory species (sheep).

Mlodawska et al. 2010. Theriogenology. 74(9):1707-12. PMID: 20932560.

Immunohistochemical localization of aromatase during the development and atresia of ovarian follicles in prepubertal horses.

Catalano et al. 2010. J Biol Chem. 285(8):5581-93. PMID: 20026603.

Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.

Sirianni et al. 2009. J Biol Chem. 284(42):28905-16. PMID: 19679653.

Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells.

Rago et al. 2007. Reprod Biol Endocrinol. 5:23. PMID: 17553131.

Cytochrome P450arom, androgen and estrogen receptors in pig sperm.

Rago et al. 2005. Reprod Biol Endocrinol. 3:72. PMID: 16372909.

Cytochrome P450 aromatase expression in human seminoma.

Pakarainen et al. 2005. Mol Endocrinol. 19(10):2591-602. PMID: 15941853.

Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles.

Fazleabas et al. 2003. Fertil Steril. 80 Suppl 2:820-7. PMID: 14505759.

Steroid receptor and aromatase expression in baboon endometriotic lesions.

Turner et al. 2002. J Endocrinol. 172(1):21-30. PMID: 11786371.

Development and validation of a new monoclonal antibody to mammalian aromatase.

Images

View Gallery
Clone H4 used to detect aromatase in pig sperm by Immunofluorescence. ...B) P450arom red brilliant light in the proximal tail of sperm with a diffuse labelling in the distal tail. Source

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.