Clone V92.1, recognizes a protein of 55-62kDa, identified as cyclin B1.
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151180 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | FACS ; IHC ; IF ; IP ; WB |
| Target: | Cyclin B1 |
| Reactivity: | Hamster ; Human ; Mouse |
| Clone: | V92.1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CCNB, CCNB1, CCNB1_HUMAN, G2 Mitotic Specific Cyclin B1Human Entrez Gene ID 891 Human SwissProt P14635 Human Unigene 2396 Human Gene Symbol CCNB1Human Chromosome Location 5q13.2 |
|---|---|
| Product description: | Clone V92.1, recognizes a protein of 55-62kDa, identified as cyclin B1. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 55-62 kDa |
| Immunogen: | Hamster Cyclin B1 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin B1 is a marker of cell proliferation and a key component of the cell cycle progression machinery. Cyclin B1 may prove to be a prognostic marker in neoplasia. V92.1 may be used to immunoprecipitate active CDK1/cyclin complexes. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Garner et al. 2002. Oncogene. 21(53):8089-104. PMID: 12444545. Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint. Minemoto et al. 2001. Exp Cell Res. 262(1):37-48. PMID: 11120603. Characterization of adriamycin-induced G2 arrest and its abrogation by caffeine in FL-amnion cells with or without p53. |
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