Microcystins are cyclic heptapeptides implicated in the impairment of liver function in various animals. They have two variable amino acid residues; in the case of the cyanotoxin MC-LR the variable amino acids are Leucine (L) and Arginine (R). Microcystin-LR is the most commonly found cyanotoxin and inhibits protein phosphatase type 1 and type 2A (PP1 […]
| Inventor | Institute |
|---|---|
| Caroline Murphy ; Richard O'Kennedy | Dublin City University |
| Cat. #: | 158335 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry |
| Application: | ELISA ; WB |
| Target: | Microcystin-LR |
| Host: | Mouse |
| Class: | Recombinant |
| Alternate name: | MC-LR, Anti-Microcystin-LR (R66S) scAb |
|---|---|
| Product description: | Microcystins are cyclic heptapeptides implicated in the impairment of liver function in various animals. They have two variable amino acid residues; in the case of the cyanotoxin MC-LR the variable amino acids are Leucine (L) and Arginine (R). Microcystin-LR is the most commonly found cyanotoxin and inhibits protein phosphatase type 1 and type 2A (PP1 and PP2A) activities in the cytoplasm of liver cells, leading to hepatocytic necrosis and haemorrhaging. Chronic exposure to microcystin is a worrying phenomenon as microcystin over an extended period of time can cause cancer through the inhibition of protein phosphatases PP1 and PP2A. |
| Conjugation: | Unconjugated |
| Immunogen: | Microcystin-LR |
| Immunogen Uniprot ID: | TBC |
| Target background: | Microcystins are cyclic heptapeptides implicated in the impairment of liver function in various animals. They have two variable amino acid residues; in the case of the cyanotoxin MC-LR the variable amino acids are Leucine (L) and Arginine (R). Microcystin-LR is the most commonly found cyanotoxin and inhibits protein phosphatase type 1 and type 2A (PP1 and PP2A) activities in the cytoplasm of liver cells, leading to hepatocytic necrosis and haemorrhaging. Chronic exposure to microcystin is a worrying phenomenon as microcystin over an extended period of time can cause cancer through the inhibition of protein phosphatases PP1 and PP2A. |
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| Format: | Liquid |
|---|---|
| Storage conditions: | Store at -20° C frozen (best practice). Avoid repeated freeze/thaw cycles. Stable at room temperature in the presence of 20% (v/v) glycerol. |
| Shipping conditions: | Dry ice |
| References: |
Murphy et al. 2018. J Immunol Methods. 463:127-133. PMID: 30321550. |
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