#151669

Anti-cROS [7-2B]

Cat. #151669

Anti-cROS [7-2B]

Cat. #: 151669

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: cROS

Class: Monoclonal

Application: IF ; IP ; Fn ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Al Charest

Institute: Tufts University

Tool Details
Target Details
Applications
Handling

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-cROS [7-2B]
  • Research fields: Cancer;Cell signaling and signal transduction;Genetics
  • Clone: 7-2B
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IF ; IP ; Fn ; WB
  • Description: c-ROS is a proto-oncogene tyrosine kinase, that is highly-expressed in a variety of tumour cell lines and belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. It is a type I integral membrane protein and may function as a growth or differentiation factor receptor. The c-ROS gene promoter region has been identified and characterized and it has been shown that the ectopic expression of c-ROS in tumors is tied to hypomethylation of a CpG island in the c-ROS promoter.
  • Immunogen: Extracellular portion of ROS amino acid 1-285 fused to Fc, transiently expressed in 293 cells and purified using PtnA column chromatography.
  • Isotype: IgG1
  • Myeloma used: Sp2/0-Ag14
  • Recommended controls: Cells transiently expressing human cROS, mouse cells expressing human cROS

Target Details

  • Target: cROS
  • Tissue cell line specificity: Cells transiently expressing human cROS, mouse cells expressing human cROS
  • Target background: c-ROS is a proto-oncogene tyrosine kinase, that is highly-expressed in a variety of tumour cell lines and belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. It is a type I integral membrane protein and may function as a growth or differentiation factor receptor. The c-ROS gene promoter region has been identified and characterized and it has been shown that the ectopic expression of c-ROS in tumors is tied to hypomethylation of a CpG island in the c-ROS promoter.

Applications

  • Application: IF ; IP ; Fn ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C