CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha.
| Institute |
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| University of Birmingham |
| Cat. #: | 151432 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Immunology |
| Application: | FACS ; IHC ; IP ; WB |
| Target: | Complement component (3d/Epstein Barr virus) receptor 2 (CR2, CD21) |
| Reactivity: | Human |
| Clone: | BU33 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Complement Component 3d Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor; EBV Receptor; C3DR; CD21 Antigen; CVID7; SLEB9; CD21; Cr2; CR |
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| Product description: | CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CR2 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CR2 expression is also gradually lost after stimulation of B cells in vitro. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. CR2 binds to CD23 and … |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | HF B1 plasmactyoid cell line, considered to be "late B like" |
| Myeloma used: | NS0 |
| Target background: | CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CR2 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CR2 expression is also gradually lost after stimulation of B cells in vitro. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. CR2 binds to CD23 and … |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Mayall et al. 2001. J Comp Pathol. 124(1):83-7. PMID: 11428193. The anti-human CD21 antibody, BU33, identifies equine B cells. Scholssman SF. et al. 1995. Leucocyte Typing V. Oxford University Press. ISBN-13: 978-0192623768 Henchoz et al. 1994. Immunology. 81(2):285-90. PMID: 7512529. Stimulation of human IgE production by a subset of anti-CD21 monoclonal antibodies: requirement of a co-signal to modulate epsilon transcripts. Bacon et al. 1993. Eur J Immunol. 23(10):2721-4. PMID: 76… |
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