#158414

Anti-cancer inhibitor of protein phosphotase 2A [4A9-1A2]

Cat. #158414

Anti-cancer inhibitor of protein phosphotase 2A [4A9-1A2]

Cat. #: 158414

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: Cancerous Inhibitor of Protein Phosphatase 2A

Class: Monoclonal

Application: WB ; IP

Reactivity: Human ; Rat ; Mouse

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Edward Chan

Institute: University of Florida Research Foundation

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-cancer inhibitor of protein phosphotase 2A [4A9-1A2]
  • Alternate name: CIP2A
  • Research fields: Cancer;Cell signaling and signal transduction
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human ; Rat ; Mouse
  • Host: Mouse
  • Application: WB ; IP
  • Description: CIP2A is an oncoprotein that inhibits PP2A tumor suppressor activity in human malignancies by preventing degredation of c-Myc and regulates the phosphorylation of many oncoproteins. CIP2A is required for malignant cellular growth and tumor formation and is overexpressed in several human cancers: head and neck squamous cell carcimona, colon cancer, gastric cancer, breast cancer, prostate cancer, and lung caner.
  • Immunogen: MAb were generated using the C-terminal third of the recombinant human protein as antigen
  • Isotype: IgG1 kappa

Target Details

  • Target: Cancerous Inhibitor of Protein Phosphatase 2A
  • Target background: CIP2A is an oncoprotein that inhibits PP2A tumor suppressor activity in human malignancies by preventing degredation of c-Myc and regulates the phosphorylation of many oncoproteins. CIP2A is required for malignant cellular growth and tumor formation and is overexpressed in several human cancers: head and neck squamous cell carcimona, colon cancer, gastric cancer, breast cancer, prostate cancer, and lung caner.

Applications

  • Application: WB ; IP

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Shipping conditions: Shipping at 4° C

References

  • Wei et al. 2019. Oncol Lett. 17(3):3211-3218. PMID: 30867751.