Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins, found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily, CEA family- contains 7 Ig-like (immunoglobulin-like) domains.
| Inventor | Institute |
|---|---|
| Lindy Durrant | University of Nottingham |
| Cat. #: | 153384 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction |
| Application: | FACS ; IHC |
| Target: | CEA/NCA |
| Reactivity: | Human |
| Clone: | 198 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CEACAM5; CEA |
|---|---|
| Product description: | Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins, found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily, CEA family- contains 7 Ig-like (immunoglobulin-like) domains. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | CEA preparation purified from colon carcinoma metastases. Tumor subcellular membranes or viable cells from CEA-producing colon carcinoma cell lines |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins, found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily, CEA family- contains 7 Ig-like (immunoglobulin-like) domains. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Reiterer et al. 2007. Cancer Res. 67(16):7765-72. PMID: 17699781. Platelet-derived growth factor receptor regulates myeloid and monocytic differentiation of HL-60 cells. Byers et al. 1988. J Immunol. 140(11):4050-5. PMID: 2453564. Potentiation of anti-carcinoembryonic antigen immunotoxin cytotoxicity by monoclonal antibodies reacting with co-expressed carcinoembryonic antigen epitopes. |
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