CD72, a member of the C-type lectin superfamily, is a 45 kDa type II transmembrane glycoprotein. It is expressed from the pro-B through to the mature B cell stage but absent in terminally differentiated plasma cells. Ligation of CD72 enhances B cell growth and proliferation.
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| University of Birmingham |
| Cat. #: | 151491 |
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| Unit size: | 100 ug |
| Research Fields: | Immunology;Stem cell biology |
| Application: | ELISA ; FACS |
| Target: | CD72 |
| Reactivity: | Human ; Mouse |
| Clone: | BU41 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CD72 Molecule; CD72 Antigen; Lyb-2; CD72b; LYB2 |
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| Product description: | CD72, a member of the C-type lectin superfamily, is a 45 kDa type II transmembrane glycoprotein. It is expressed from the pro-B through to the mature B cell stage but absent in terminally differentiated plasma cells. Ligation of CD72 enhances B cell growth and proliferation. |
| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | CD72, a member of the C-type lectin superfamily, is a 45 kDa type II transmembrane glycoprotein. It is expressed from the pro-B through to the mature B cell stage but absent in terminally differentiated plasma cells. Ligation of CD72 enhances B cell growth and proliferation. |
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| Format: | Liquid |
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| Concentration: | 1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Knapp W. et al. 1989. Leukocyte Typing IV. Oxford University Press. ISBN-13: 978-0192618672 Hollenbaugh et al. 1992. EMBO J. 11(12):4313-21. PMID: 1385114. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. Luo et al. 1992. J Immunol. 148(6):1630-4. PMID: 1371783. Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72). |
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