Cat. #151082
Anti-CD45 [C11]
Cat. #: 151082
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45)
Class: Monoclonal
Application: IHC ; IP
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Peter Beverley
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD45 [C11]
- Alternate name: Anti-PTPRC
- Research fields: Tissue-specific biology;Cell biology;Cell signaling and signal transduction;Immunology;Neurobiology;Stem cell biology
- Clone: C11
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 180-222 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: IHC ; IP
- Description: PTPRC, also known as CD45, is a transmembrane tyrosine phosphatase that is present on all leukocytes. It regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours.
- Immunogen: Human lymphocytes
- Isotype: IgG2a
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45)
- Molecular weight: 180-222 kDa
- Target background: PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours.
Applications
- Application: IHC ; IP
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Williams et al. 2003. Clin Exp Immunol. 131(1):68-74. PMID: 12519388.
- Dipeptidyl peptidase IV on activated T cells as a target molecule for therapy of rheumatoid arthritis.
