C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours.
| Inventor | Institute |
|---|---|
| Peter Beverley | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151082 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Immunology;Neurobiology;Stem cell biology;Tissue-specific biology |
| Application: | IHC ; IP |
| Target: | Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45) |
| Reactivity: | Human |
| Clone: | C11 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Anti-PTPRC |
|---|---|
| Product description: | PTPRC, also known as CD45, is a transmembrane tyrosine phosphatase that is present on all leukocytes. It regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 180-222 kDa |
| Immunogen: | Human lymphocytes |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Williams et al. 2003. Clin Exp Immunol. 131(1):68-74. PMID: 12519388. Dipeptidyl peptidase IV on activated T cells as a target molecule for therapy of rheumatoid arthritis. |
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