Anti-Cadherin 6 [2B6-D8]

From Shimazui et al Clin Cancer Res. 1998 Oct;4(10):2419-24. “In many carcinomas, E-cadherin is considered to be a prognostic marker for patient survivals, and its decreased expression is associated with metastatic disease. Among renal cell carcinomas (RCCs), however, only 20% of tumors express E-cadherin, whereas a much higher percentage express other cadherins, e.g., N-cadherin and […]

Contributors

Inventor Institute
Jack A Schalken Radboud University Medical Center (UMC)
Cat. #: 160536
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology
Application: IHC
Target: Cadherin-6
Host: Mouse
Class: Monoclonal
Alternate name: Cadherin 6, CDH6
Product description: From Shimazui et al Clin Cancer Res. 1998 Oct;4(10):2419-24. "In many carcinomas, E-cadherin is considered to be a prognostic marker for patient survivals, and its decreased expression is associated with metastatic disease. Among renal cell carcinomas (RCCs), however, only 20% of tumors express E-cadherin, whereas a much higher percentage express other cadherins, e.g., N-cadherin and cadherin-6. Among these cadherins expressed in RCCs, cadherin-6 has been identified as a major cadherin in the renal proximal tubules and in the tumors themselves." The inventors of this reagent found that " These results suggest that cadherin-6 is a major cadherin playing an essential role in cell-cell adhesion in E-cadherin-absent RCC."
Conjugation: Unconjugated
Immunogen: glutathione S-transferase (GST) fusion extracellular domain of human cadherin-6a
Myeloma used: Sp2/0-Ag14
Target background: From Shimazui et al Clin Cancer Res. 1998 Oct;4(10):2419-24. "In many carcinomas, E-cadherin is considered to be a prognostic marker for patient survivals, and its decreased expression is associated with metastatic disease. Among renal cell carcinomas (RCCs), however, only 20% of tumors express E-cadherin, whereas a much higher percentage express other cadherins, e.g., N-cadherin and cadherin-6. Among these cadherins expressed in RCCs, cadherin-6 has been identified as a major cadherin in the renal proximal tubules and in the tumors themselves." The inventors of this reagent found that " These results suggest that cadherin-6 is a major cadherin playing an essential role in cell-cell adhesion in E-cadherin-absent RCC."
Format: Liquid
Shipping conditions: Dry ice
References:

Shimazui et al. 1998. Clin Cancer Res. 4(10):2419-24. PMID: 9796973.

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From Shimazui et al Clin Cancer Res. 1998 Oct;4(10)

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