APC4 contains WD repeats and has a molecular weight of approximately 92 kD. APC4 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase.
| Inventor | Institute |
|---|---|
| Jonathon Pines | University of Cambridge |
| Cat. #: | 151500 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry;Cell biology |
| Application: | IP ; IP ; WB |
| Target: | Anaphase-promoting complex (APC) 4 |
| Reactivity: | Human |
| Clone: | CIV1.1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | APC4 is a component of the anaphase-promoting complex (APC). The APC complex functions as an ubiquitin ligase which promotes the transition from metaphase to anaphase of the cell cycle. APC4 contains WD repeats and has a molecular weight of approximately 92 kD. APC4 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Molecular weight: | 92 kDa |
| Immunogen: | C-terminus of APC4 |
| Target background: | APC4 is a component of the anaphase-promoting complex (APC). The APC complex functions as an ubiquitin ligase which promotes the transition from metaphase to anaphase of the cell cycle. APC4 contains WD repeats and has a molecular weight of approximately 92 kD. APC4 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
Di Fiore et al. 2015. Dev Cell. 32(3):358-72. PMID: 25669885. The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators. Sedgwick et al. 2013. EMBO J. 32(2):303-14. PMID: 23288039. Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. |
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