Cat. #151500
Anti-APC4 [CIV1.1]
Cat. #: 151500
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Anaphase-promoting complex (APC) 4
Class: Monoclonal
Application: IP ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Jonathon Pines
Institute: University of Cambridge
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-APC4 [CIV1.1]
- Research fields: Biochemistry;Cell biology
- Clone: CIV1.1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Molecular weight: 92 kDa
- Reactivity: Human
- Host: Mouse
- Application: IP ; IP ; WB
- Description: APC4 is a component of the anaphase-promoting complex (APC). The APC complex functions as an ubiquitin ligase which promotes the transition from metaphase to anaphase of the cell cycle. APC4 contains WD repeats and has a molecular weight of approximately 92 kD. APC4 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase.
- Immunogen: C-terminus of APC4
- Isotype: IgG
- Recommended controls: Purified APC/C by silver and mass spectrometry
Target Details
- Target: Anaphase-promoting complex (APC) 4
- Molecular weight: 92 kDa
- Tissue cell line specificity: Mouse
- Target background: APC4 is a component of the anaphase-promoting complex (APC). The APC complex functions as an ubiquitin ligase which promotes the transition from metaphase to anaphase of the cell cycle. APC4 contains WD repeats and has a molecular weight of approximately 92 kD. APC4 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase.
Applications
- Application: IP ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -80° C
- Shipping conditions: Dry ice
References
- Di Fiore et al. 2015. Dev Cell. 32(3):358-72. PMID: 25669885.
- The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators.
- Sedgwick et al. 2013. EMBO J. 32(2):303-14. PMID: 23288039.
- Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.
