TOV-1946 cell line

Epithelial ovarian cancer cell line derived from poorly differentiated serous solid tumors

Contributors

Inventor Institute
Anne-Marie Mes-Masson and Diane Provencher Centre Hospitalier de L’université de Montréal
Cat. #: 161770
Cancer types: Gynaecologic cancer
Research Fields: Cancer
Organism: Human
Tissue: Derived from poorly differentiated serous solid tumors
Gender: Female
Morphology: Able to form loose aggregate of cells. Expressed Krt7
Growth properties: Adherent
Primary citation: Ouellet et al. 2008. BMC Cancer. (8):152. PMID: 18507860
Alternate name: TOV-1946
Product description: Epithelial ovarian cancer cell line derived from poorly differentiated serous solid tumors. Cell line was derived from solid tumor of chemotherapy naive patient who presented poorly differentiated (grade 3) serous papillary cystadenocarcinoma at stage IIC
Gender: Female
CRISPR: No
Production details: Established using the Scrape method where tumor tissue was scraped into a 100mm plate with complete OSE medium and maintained for 40 days with medium replaced weekly. After 40 days, 80% confluence was attained and cells were divided intwo 2 petri dishes and further divided in a proportion of 2:3 once a week for the first 15 passages and 1:2 twice a week until passage 70. Subsequently, cells were divded in a proportion of 1:5 twice a week.
Additional notes: Patient 1946 had no known familial history of cancer and passed from post-operative complications
Receptors of note: No
Growth medium: OSE medium contains 10% FBS, 0.5ug/mL amphotericin B and 50 ug/mL gentamicin
Atmosphere: Hypoxic condition of 5%O2 and 5%CO2
References:

Sauriol et al. 2023. Sci Rep. 27

13(1):3334. PMID: 36849518 Sevinyan et al. 2022. Cancers (Basel). 16

14(22):5628. PMID: 36428724 Brodeur et al. 2021. Sci Rep. 14

11(1):18183. PMID: 34521878 Communal et al. 2021. Int J Mol Sci. 18

22(10):5325. PMID: 34070214 Patra et al. 2020 PLoS One. 31

15(12):e0244549. PMID: 33382759

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