Anti-ORF33 [ORF33]

This mouse monoclonal antibody for KSHV (tegument) protein open reading frame 33 (ORF 33) was generated using a bacterially produced recombinant protein as an antigen.

Contributors

Inventor Institute
Fanxiu Zhu Florida State University Research Foundation
SKU: 160638
Product description: Kaposi’s sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi’s sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). This mouse monoclonal antibody for KSHV (tegument) protein open reading frame 33 (ORF 33) was generated using a bacterially produced recombinant protein as an antigen. ORF33 has been shown to be a crucial component of progeny virion production in conjunction with ORF45. ORF33 binding domain has been mapped to the highly conserved carboxyl-terminal 19 aa of ORF 45 and to USP7 binding domain according to Gillen et al., 2015. ORF33 has also been shown to interact with ORF38.
Conjugation: Unconjugated
Isotype: IgG
Immunogen: A bacterially produced recombinant ORF 33 protein was used as an antigen
Cat. #: 160638
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Genetics;Microbiology
Application: WB
Target: Open Reading Frame 33
Reactivity: Other Species
Host: Mouse
Class: Monoclonal
Target background: Kaposi’s sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi’s sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). This mouse monoclonal antibody for KSHV (tegument) protein open reading frame 33 (ORF 33) was generated using a bacterially produced recombinant protein as an antigen. ORF33 has been shown to be a crucial component of progeny virion production in conjunction with ORF45. ORF33 binding domain has been mapped to the highly conserved carboxyl-terminal 19 aa of ORF 45 and to USP7 binding domain according to Gillen et al., 2015. ORF33 has also been shown to interact with ORF38.
Format: Liquid
Shipping conditions: Dry ice
References:

Wu et al. 2016. J Virol. 90(4):1741-56. PMID: 26637455.

Gillen et al. 2015. J Virol. 89(9):4918-31. PMID: 25694600.

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