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Cat. #157806
Anti-DNA [m111-c2]
Cat. #: 157806
Unit size: 100 ug
Availability: 10-12 weeks
Target: ssDNA and/or dsDNA
Class: Monoclonal
Application: ELISA
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Tony Marion
Institute: The University of Tennessee Health Science Center (UTHSC)
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-DNA [m111-c2]
- Research fields: Immunology
- Class: Monoclonal
- Conjugation: Unconjugated
- Host: Mouse
- Application: ELISA
- Description: Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.
- Immunogen uniprot id: N/A
- Isotype: IgG2a
Target Details
- Target: ssDNA and/or dsDNA
- Target background: Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.
Applications
- Application: ELISA
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Dry ice
References
- Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.
- Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.
- Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.
