HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family.
| Institute |
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| Netherlands Cancer Institute |
| Cat. #: | 154729 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction |
| Application: | IHC ; IF ; IP ; WB |
| Target: | cErbB2/HER-2 |
| Reactivity: | Human ; Mouse ; Rat |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | NEU |
|---|---|
| Product description: | HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 185 kDa |
| Immunogen: | Mouse immunized with a synthetic peptide TAENPEYLGLDVPV corresponding to amino acid residues |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -20° C |
| Shipping conditions: | Dry ice |
| References: |
Ttu et al. 1994. Cancer. 73(9):2359-65. PMID: 7909490. Marks et al. 1994. Ann Surg. 219(4):332-41. PMID: 7909221. van Leeuwen et al. 1990. Oncogene. 5(4):497-503. PMID: 1970152. van de Vijver et al. 1988. N Engl J Med. 319(19):1239-45. PMID: 2903446. Varley et al. 1987. Oncogene. 1(4):423-30. PMID: 3330785. Di Fiore et al. 1987. Science. 237(4811):178-82. PMID: 2885917. Slamon et al. 1987. Science. 235(4785):177-82. PMID: 3798106. Yamamoto et al. 1986. Nature. 319(6050):230-4. PMID: 3003577. Bargmann et al. 1986. Nature. 319(6050):226-30. PMID: 3945311. Blick et al. 1984. Blood. 64(6):1234-9. PMID: 6208953. |
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