Family 1 sibling – LAD-III Lymphoblastoid Cell Line

An EBV-transformed B lymphoblastoid cell line (LCL) derived from the sister of a Maltese subject that has Leukocyte Adhesion Deficiency-III (LAD-III) with a mutation in the kindlin-3 gene.

Contributors

Inventor Institute
Nancy Hogg Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 153763
Unit size: 1×10^6 cells / vial
Research Fields: Cell biology;Immunology
Organism: Human
Tissue: Blood
Growth properties: Suspension, lymphoblastoid cell line
Cancer Types In Detail: Leukocyte Adhesion Deficiency-III (LAD-III)
Alternate name: Fermitin family homolog 3, MIG2-like protein, Unc-112-related protein 2
Product description: An EBV-transformed B lymphoblastoid cell line (LCL) derived from the sister of a Maltese subject that has Leukocyte Adhesion Deficiency-III (LAD-III) with a mutation in the kindlin-3 gene. LCLs are also available from the subject, father and mother. This cell line was derived from 'Family 1 sibling' as described in Svensson et al. 2009. N.Nat Med. 2009 Mar;15(3):306-12. PMID: 1923446
Disease: Cancer
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Growth medium: RPMI-1640 + 10% FCS
Mycoplasma free: Yes
Biosafety level: 1
References:

Svensson et al. 2009. Nat Med. 15(3):306-12. PMID: 19234463.

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.

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