Anti-p53 [PAb242]

Monoclonal antibody directed against p53, binding a distinct epitope in amino acids 18-27 at the N-terminus

Contributors

Inventor Institute
David Lane Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 153297
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Other
Research Fields: Apoptosis and autophagy;Cancer;Cell biology;Genetics
Application: ELISA ; IHC ; IF ; IP ; WB
Target: p53
Reactivity: Mouse
Clone: PAb 242
Host: Mouse
Class: Monoclonal
Primary citation: Yewdell et al. 1986. J Virol. 59(2):444-52. PMID: 2426467.
Alternate name: Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, FLJ92943, LFS1, Mutant tumor protein 53, p53, p53 tumor suppressor, P53_HUMAN, Phosphoprotein p53, Tp53, Transformation related protein 53, TRP53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53
Product description: Monoclonal antibody directed against p53, binding a distinct epitope in amino acids 18-27 at the N-terminus
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 53 kDa
Immunogen: SV40-transformed cell line BALB/c SVA31 E7
Immunogen Uniprot ID: P04637
Myeloma used: Sp2/0-Ag14
Target background: Anti-p53 binds p53 protein, a crucial tumour suppressor protein, implicated in over 50% of cancers. p53 is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. p53 is involved in many mechanisms of anti-cancer function and plays a role in apoptosis, genomic stability, cell cycle regulation, and inhibition of angiogenesis. p53 is known as the guardian of the genome as it functions to prevent gene mutation….
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Sabapathy et al. 2019. J Mol Cell Biol. 11(4):317-329. PMID: 30907951.

Eng et al. 2016. Protein Eng Des Sel. 29(1):11-21. PMID: 26508747.

Mayelzadeh et al. 2007. Oncogene. 26(21):2955-63. PMID: 17130840.

Lane et al. 1996. Oncogene. 12(11):2461-6. PMID: 8649788.

Yewdell et al. 1986. J Virol. 59(2):444-52. PMID: 2426467.

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