SDHB Floxed Mouse

SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle

Contributors

Inventor Institute
Eyal Gottlieb Cancer Research UK, Glasgow: The Beatson Institute
Cat. #: 153295
Research Fields: Cancer;Drug development;Genetics;Metabolism
Target: Succinate dehydrogenase
disease: Cancer
Model: Transgenic
Zygosity: Homozygous
Strain: C57BL/6
Alternate name: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
Product description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation.
Conditional description: Exon 3 of the succinate dehydrogenase can be deleted upon Cre recombinase expression as this exon is flanked with lox P sequences
Genetic background: Backcrossed 10 times into C57/BL6
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

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