SDHB Floxed Mouse

SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle

Contributors

Inventor Institute
Eyal Gottlieb Cancer Research UK, Glasgow: The Beatson Institute
SKU: 153295
Product description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation.
Alternate name: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
Conditional description: Exon 3 of the succinate dehydrogenase can be deleted upon Cre recombinase expression as this exon is flanked with lox P sequences
Cat. #: 153295
Research Fields: Cancer; Drug development; Genetics; Metabolism
Target: Succinate dehydrogenase
Disease: Cancer
Model: Transgenic
Zygosity: Homozygous
Strain: C57BL/6
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

Related Tools for Mouse models

Cat. # Tool Name
153294 Sdhb fl/fl Cell Line Key Info View Tool
153292 Sdhb -/- CL 5 Cell Line Key Info View Tool
153293 Sdhb -/- CL 7 Cell Line Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.