Sdhb -/- CL 7 Cell Line

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SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and losing this function is associated with cancer formation.

Contributors

Inventor Institute
Eyal Gottlieb Cancer Research UK, Glasgow: The Beatson Institute
SKU: 153293
Product description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and losing this function is associated with cancer formation.
Alternate name: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
Cellosaurus ID: CVCL_HG13
Disease: Cancer
Cat. #: 153293
Provenance and Ownership: The Sdhb -/- CL 7 Cell Line is owned by Cancer Research UK. CancerTools supplies the Sdhb -/- CL 7 Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Sdhb -/- CL 7 Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Unit size: 1×10^6 cells / vial
Research Fields: Cancer; Drug development; Metabolism
Organism: Mouse
Tissue: Kidney
Model: Knock-Out
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Mycoplasma free: Yes
Biosafety level: 1
References:

Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

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