S-100 protein is an acidic protein antigen present on certain cells and useful as a marker in anatomic pathology.
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| Cat. #: | 151402 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Other |
| Application: | IHC |
| Target: | S100 |
| Reactivity: | Human |
| Clone: | S1-61 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | S-100 protein is an acidic protein antigen present on certain cells and useful as a marker in anatomic pathology. The name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. The protein binds calcium and is structurally similar to calmodulin. The function of S-100 is unknown. S-100 is normally present in cells derived from the neural crest (Schwann cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Lang… |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | S-100 protein conjugated to methylated BSA |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | S-100 protein is an acidic protein antigen present on certain cells and useful as a marker in anatomic pathology. The name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. The protein binds calcium and is structurally similar to calmodulin. The function of S-100 is unknown. S-100 is normally present in cells derived from the neural crest (Schwann cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Lang… |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Vanstapel et al. 1986. Am J Clin Pathol. 85(2):160-8. PMID: 2418676. New sites of human S-100 immunoreactivity detected with monoclonal antibodies. Vanstapel et al. 1985. Lab Invest. 52(2):232-8. PMID: 2578587. Production of monoclonal antibodies directed against antigenic determinants common to the alpha- and beta-chain of bovine brain S-100 protein. |
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