PtdIns 4,5-P2 is a membrane phospholipid and an important component of signal transduction pathways.
| Inventor | Institute |
|---|---|
| Giampietro Schiavo | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151237 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Neurobiology |
| Application: | ChIP ; ELISA ; IHC ; IF ; IP ; Fn ; DB |
| Target: | Phosphatidylinositol biphosphate (PIP2) |
| Clone: | PIP2 2C11 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | PtdIns 4,5-P2 is a membrane phospholipid and an important component of signal transduction pathways. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Immunogen: | Liposomes (prepared in PBS with lipid A, phosphatidylcholine (PC) and cholesterol) containing synthetic di-palmitoyl PtdIns(4,5)P2. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | PtdIns 4,5-P2 is a membrane phospholipid and an important component of signal transduction pathways. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Toska et al. 2014. Oncogene. 33(43):5100-8. PMID: 24166496. Prohibitin is required for transcriptional repression by the WT1-BASP1 complex. Ozkucur et al. 2011. BMC Cell Biol. 12:4. PMID: 21255452. Persistent directional cell migration requires ion transport proteins as direction sensors and membrane potential differences in order to maintain directedness. Osborne et al. 2001. J Cell Sci. 114(Pt 13):2501-11. PMID: 11559758. Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing. Thomas et al. 1999. Biochem Soc Trans. 27(4):648-52. PMID: 10917659. Generation of phosphatidylinositol-specific antibodies and their characterization. |
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