TVG 261 is useful for detection of protein in cervical lesions.
| Institute |
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| University of Cambridge |
| Cat. #: | 151167 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Gynaecologic cancer |
| Research Fields: | Cancer;Microbiology |
| Application: | IP ; WB ; ELISA ; IF ; WB |
| Target: | Human Papilloma virus-16 early protein 2 (HPV16 E2) |
| Reactivity: | Human papilloma virus |
| Clone: | TVG 261 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | TVG 261 is useful for detection of protein in cervical lesions. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 10 kDa |
| Immunogen: | Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2 (generated from an expression vector in which the E2 ORF was cloned in frame with malE). |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. E1 and E2 are proteins involved in the regulation of viral DNA replication. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | '-15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Evans et al. 2019. J Virol. 93(4):. PMID: 30518656. Ludwig et al. 2018. Front Oncol. 8:445. PMID: 30370252. Evans et al. 2017. Oncotarget. 8(47):81892-81909. PMID: 29137231. Campos-Len et al. 2017. J Virol. 91(5):. PMID: 28031358. A point mutation within CD45 exon A is the cause of variant CD45RA splicing in humans. Hibma et al. 1995. Eur J Biochem. 229(2):517-25. PMID: 7744075. |
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