C1P5 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
| Inventor | Institute |
|---|---|
| Lawrence Banks | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151083 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Gynaecologic cancer |
| Research Fields: | Cancer;Microbiology |
| Application: | IHC ; IP ; WB |
| Target: | Human Papilloma Virus-16 and 18 early protein 6 (HPV16E6 & HPV18 E6) |
| Reactivity: | Human papilloma virus |
| Clone: | C1P5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | C1P5 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 15.8 kDa, 17 kDa |
| Immunogen: | Gel-purified HPV-18 E6-beta galactosidase fusion protein |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.81 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | '-15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Xie et al. 2014. Oncogene. 33(8):1037-46. PMID: 23474763. Herfs et al. 2012. Proc Natl Acad Sci U S A. 109(26):10516-21. PMID: 22689991. Lawson et al. 2009. Br J Cancer. 101(8):1351-6. PMID: 19773762. Zhang et al. 2005. J Biol Chem. 280(39):33165-77. PMID: 15983032. Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140. |
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