Antibody for PAX9 (Paired Box 9, also know as STHAG3), a PAX transcription factor. The PAX transcription factor genes have critical roles in foetal development and cancer growth.
| Institute |
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| Helmholtz Munich Core Facility Monoclonal Antibodies |
| Cat. #: | 162375 |
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| Tool sub type: | Primary antibody |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Developmental biology |
| Application: | WB |
| Target: | Human/murine PAX9 |
| Reactivity: | Human, mouse |
| Clone: | PAX9 7C2 |
| Host: | Rat |
| Class: | Monoclonal |
| Primary citation: | Gerber et al. 2002. J. Pathol. 197: 293-297. PMID: 12115874 |
| Alternate name: | Anti human/murine PAX9 monoclonal antibody (clone PAX9 7C2) |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1, k |
| Target background: | PAX9 has prognostic significance in esophageal squamous cell carcinoma (ESCC) and predicts radiation sensitivity. Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus. PAX9 expression has been shown to mediate oncogene-induced cell survival in oral squamous cell carcinoma (Lee et al., 2008). On the other hand progressive loss of PAX9 expression correlates with increasing malignancy in esophageal cancers (Gerber et al., 2002) |
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| References: |
Gerber et al. 2002. J. Pathol. 197: 293-297. PMID: 12115874 Jonker et al. 2004. Mech. Dev. 121: 1313-1322. PMID: 15454262 |
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