| Inventor | Institute |
|---|---|
| Prof Emanuele Buratti | International Centre For Genetic Engineering And Biotechnology (ICGEB) |
| SKU: | 153787 |
|---|---|
| Product description: | Concentration 1.2mg/ml |
| Alternate name: | TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10 |
| Additional notes: | The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). The N-terminal region of TDP-43 is a highly structured sequence that contributes to the reversible dimerization and oligomerization of this protein. It contains a bipartite Nuclear Localization Signal that ensures the predominant nuclear localization of TDP-43. |
| Cat. #: | 153787 |
|---|---|
| Tool sub type: | pQE30 |
| Research Fields: | Genetics; Neurobiology; Microbiology |
| Target: | TDP43 N-terminal domain 1-102 |
| Backbone size without insert: | 3461 |
| Bacterial resistance: | Ampicillin |
| Application notes: | Concentration 1.2mg/ml |
|---|
| References: |
MompeĂĄn et al. 2016. FEBS J. 283(7):1242-60. PMID: 26756435. The TDP-43 N-terminal domain structure at high resolution. |
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