| Inventor | Institute |
|---|---|
| Prof Emanuele Buratti | International Centre For Genetic Engineering And Biotechnology (ICGEB) |
| SKU: | 153789 |
|---|---|
| Product description: | Concentration 1.5mg/ml |
| Alternate name: | TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10 |
| Additional notes: | The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). This is a mutant N-terminal domain of TDP-43 that cannot fold properly |
| Cat. #: | 153789 |
|---|---|
| Tool sub type: | pQE30 |
| Research Fields: | Genetics; Neurobiology; Microbiology |
| Target: | Mutant TDP43 N-terminal domain 1-102 |
| Backbone size without insert: | 3461 |
| Bacterial resistance: | Ampicillin |
| Application notes: | Concentration 1.5mg/ml |
|---|
| References: |
MompeĂĄn et al. 2017. J Biol Chem. 292(28):11992-12006. PMID: 28566288. Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions. |
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