CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections.
| Inventor | Institute |
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| Jacqueline Cordell | University of Oxford |
| SKU: | 151374 |
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| Product description: | The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections. |
| Alternate name: | CD79a Molecule; Membrane-Bound Immunoglobulin-Associated Protein; Surface IgM-Associated Protein; MB-1 Membrane Glycoprotein; Ig-Alpha; IGA; CD79a Antigen; MB1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide of 14 amino acids representing residues 202-216 of the human mb-1 cDNA sequence. |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151374 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Immunology;Stem cell biology |
| Application: | FACS ; IHC ; IP ; WB |
| Target: | CD79a (mb1) |
| Reactivity: | Bovine ; Chicken ; Horse ; Human ; Guinea Pig ; Mouse ; Opossum ; Pig ; Primate ; Rat ; Rabbit |
| Clone: | HM57 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Mason et al. 1995. Blood. 86(4):1453-9. PMID: 7632952. CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples. Jones et al. 1993. J Immunol. 150(12):5429-35. PMID: 8515069. Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies. Mason et al. 1992. Eur J Immunol. 22(10):2753-6. PMID: 1396979. The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation. Mason et al. 1991. J Immunol. 147(11):2474-82. PMID: 1747162. The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells. van Noesel et al. 1991. J Immunol. 146(11):3881-8. PMID: 2033258. The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene. |
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