This model organism recapitulates many molecular features of human leukaemia<U+0092>s induced by the TLX family of TF oncogenes.
| Inventor | Institute |
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| Adolfo Ferrando | The Trustees of Columbia University in the City of New York |
| SKU: | 154093 |
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| Product description: | TLX1 is an orphan homeobox gene. It was originally discovered in association with 4-7% of cases of T cell acute lymphoblastic leukaemias harbouring a t(10;14)(q24;q11) cytogenetic abnormality. Research showed the presence of the TLX1 gene on chromosome 10q24 juxtaposed with the T cell receptor (TCR) delta regulatory elements on chromosome 10, resulting in aberrant over-expression of the full and intact TLX1 gene. Juxtaposition with the TCR alpha locus was also seen. Elevated TLX1 expression in leukemic blasts is also detected in the absence of a translocation in ~50% (37/76) of paediatric T-ALL cases, as well as rare cases of B-AL. Clinically, TLX1+ T-ALLs are associated with a genetic signature associated with maturation arrest at an early cortical thymocyte stage of T cell development. This model organism recapitulates many molecular features of human leukaemias induced by the TLX family of TF oncogenes. |
| Alternate name: | T Cell Leukemia Homeobox 1, Homeo Box-11, Proto-Oncogene TCL-3, HOX11, TCL3 |
| Conditional: | No |
| Genetic background: | The human TLX1 cDNA was amplified by PCR using BamHI restriction site containing primers and cDNA of the human T-cell leukemia cell line ALL-SIL as template and was cloned in the pUC1017 vector, downstream of the mouse T-cell specific p56Lck proximal promoter |
| Production details: | The human TLX1 cDNA was amplified by PCR using BamHI restriction site containing primers and cDNA of the human T-cell leukemia cell line ALL-SIL as template and was cloned in the pUC1017 vector, downstream of the mouse T-cell specific p56Lck proximal promoter |
| Additional notes: | Transgenic mouse expressing human transcription factor Tlx1 in T cell progenitors under control of the LCK promoter |
| Cat. #: | 154093 |
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| Research Fields: | Cancer; Immunology |
| Target: | TLX1 |
| Disease: | T cell acute lymphoblastic leukemia |
| Model: | Transgenic |
| Strain: | C57BL/6 |
| Shipping conditions: | Embryo/Spermatoza- Dry Ice |
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| References: |
De Keersmaecker et al. 2010. Nat Med. 16(11):1321-7. PMID: 20972433. The TLX1 oncogene drives aneuploidy in T cell transformation. |
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