p23+/- Mouse

In vivo study of p23 knockout, golgi apparatus and early secretory pathway function

Contributors

Inventor Institute
Mike Owen Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151467
Research Fields: Cancer;Cell signaling and signal transduction;Genetics;Immunology
Target: p23
Zygosity: Heterozygous
Strain: 129/C57BL/6
Phenotype: Golgi apparatus abnormalities
Product description: In vivo study of p23 knockout, golgi apparatus and early secretory pathway function
Production details: A p23 targeting vector, constructed from genomic fragments, but replacing exon 1 of the p23 gene with a resistance marker, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, and injected into C57BL/6 blastocysts. Chimeric offspring were mated to C57BL/6 mice to generate mice heterozygous for the p23 knockout allele, p23+/- mice.
Additional notes: Genetic Bkg: 129/C57BL/6. Zygosity: Heterozygous
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Denzel et al. 2000. Curr Biol. 10(1):55-8. PMID: 10660306.

The p24 family member p23 is required for early embryonic development.

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