MAGL Knockout mouse

Useful model to study MAGL-deficiency. Animals might be useful for studies, e.g. on energy metabolism or endocannabinoid signalling.

Contributors

Inventor Institute
Robert Zimmermann ; Franz Radner University of Graz
SKU: 160871
Product description: Useful model to study MAGL-deficiency. Animals might be useful for studies, e.g. on energy metabolism or endocannabinoid signalling.
Alternate name: MGL, Mgll, Magl
Conditional: No
Genetic background: These mice were generated using HM1-ES cells. ES cell clones were injected into C57BL/6J blastocysts to enable coat colour selection of the chimeras. Mice were subsequently backcrossed to C57BL/6J (≥ 10 generations). When kept as a homozygous colony, mice are backcrossed regularly to C57BL/6J to avoid generation of subpopulations.
Production details: A floxed neomycin resistance cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed Mgll exon 3 and 4 and the selection cassette. Further details are available upon request
Cat. #: 160871
Research Fields: Cell signaling and signal transduction;Metabolism
Target: Monoglyceride lipase; monoacyl glycerol lipase
Model: Knock-Out
Zygosity: Homozygous
Strain: C57BL/6J
Phenotype: These mice display a mildly attenuated peripheral lipolysis, and are resistant to diet-induced insulin resistance and hepatic steatosis. Further, these mice display a desensitization of intestinal cannabinoid receptor type 1, which leads to accelerated colonic propulsion.
References:

26075589

Taschler et al. 2011. J Biol Chem. 286(20):17467-77. PMID: 21454566.

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