In vivo study of Lef1 activity in skin; model for hair growth & follicle formation; disease model for skin tumour formation (sebaceous adenoma, sebeoma, squamous papilloma)
| Inventor | Institute |
|---|---|
| Fiona Watt | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151564 |
|---|---|
| Product description: | In vivo study of Lef1 activity in skin; model for hair growth & follicle formation; disease model for skin tumour formation (sebaceous adenoma, sebeoma, squamous papilloma) |
| Conditional: | Yes |
| Conditional description: | Conditional expression of deltaN-Lef1 under Keratin 14 promoter giving tissue-specific epidermal expression. |
| Genetic background: | A deltaNLef1 transgene vector, containing an N-terminally deleted mouse Lef1 cDNA under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines. |
| Production details: | A deltaNLef1 transgene vector, containing an N-terminally deleted mouse Lef1 cDNA under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines. |
| Cat. #: | 151564 |
|---|---|
| Cancer types: | Skin cancer |
| Research Fields: | Cancer; Cell signaling and signal transduction; Developmental biology; Genetics; Stem cell biology |
| Target: | Lef1 N-terminal mutant (constituitive transcirptional activity) |
| Disease: | Cancer |
| Phenotype: | Tumourigenesis (skin); skin abnormalities (hair follicle, sebaceous gland) |
| Shipping conditions: | Embryo/Spermatoza- Dry Ice |
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| References: |
Niemann et al. 2002. Development. 129(1):95-109. PMID: 11782404. Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. |
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