In vivo study of beta-catenin activation in skin; model for hair growth & follicle formation;
| Inventor | Institute |
|---|---|
| Fiona Watt | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151565 |
|---|---|
| Product description: | In vivo study of beta-catenin activation in skin; model for hair growth & follicle formation; |
| Conditional: | Yes |
| Conditional description: | Conditional expression of deltaNbeta-cateninER under Keratin 14 promoter giving tissue-specific epidermal expression. |
| Genetic background: | A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines. |
| Production details: | A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines. |
| Cat. #: | 151565 |
|---|---|
| Cancer types: | Colorectal cancer |
| Research Fields: | Cancer;Cell signaling and signal transduction;Genetics;Neurobiology;Stem cell biology;Tissue-specific biology |
| Target: | Beta-catenin N-terminal truncation (deltaNbeta-catenin) fused with estrogen receptor (ER) |
| Disease: | Cancer |
| Model: | Knock-Out |
| Phenotype: | Skin abnormalities (hair follicle); |
| Shipping conditions: | Embryo/Spermatoza- Dry Ice |
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