Useful model for the generation of tissue/cell specific G0S2-deficient mice. Animals might be useful for studies, e.g.on energy metabolism or oncology.
| Inventor | Institute |
|---|---|
| Franz Radner | University of Graz |
| SKU: | 160867 |
|---|---|
| Product description: | seful model for the generation of tissue/cell specific G0S2-deficient mice. Animals might be useful for studies, e.g.on energy metabolism or oncology. |
| Alternate name: | G0/G1 swithc gene 2 |
| Conditional: | Yes |
| Conditional description: | Flox flanked gene ready for deletion |
| Genetic background: | These mice were generated using HM1-ES cells. ES cell clones were injected into C57BL/6J blastocysts to enable coat colour selection of the chimeras. Mice were subsequently backcrossed to C57BL/6J (âĽÂ 10 generations). When kept as a homozygous colony, mice are backcrossed regularly to C57BL/6J to avoid generation of subpopulations. |
| Production details: | The whole G0s2 gene sequence was targeted and flanked by loxP sites. Further details are available upon request. |
| Cat. #: | 160867 |
|---|---|
| Research Fields: | Apoptosis and autophagy;Cancer;Cell biology;Metabolism |
| Target: | G0/G1 switch gene 2 |
| Model: | Knock-Out |
| Zygosity: | Homozygous |
| Strain: | C57BL/6J |
| Phenotype: | These mice are conditional ready, and phenotypical identical to C57BL/6J mice. |
| References: |
Heier et al. 2015. J Biol Chem. 290(43):26141-50. PMID: 26350455. |
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