CXCR3-GFP knock-in mouse

CXCR3 ligands are produced in extremely high levels during inflammation and infection, but they may also be possible targets for development of therapeutics for autoimmune and cancer diseases.

Contributors

Inventor Institute
Abhay Satoskar Ohio State University
SKU: 157948
Product description: Chemokines are typically small, secreted molecules that participate in leukocyte trafficking, recruitment, and activation. They also play roles in normal and pathological processes including allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth and metastasis. CXC chemokine receptor 3 (CXCR3) is expressed by natural killer cells, neutrophils, T cells and plasmacytoid dendritic cells. CXCR3 ligands are produced in extremely high levels during inflammation and infection, but they may also be possible targets for development of therapeutics for autoimmune and cancer diseases. There is a significant need for animal models to track and investigate CXCR3 expressing cells for diagnostic and therapeutic tool development.
Cat. #: 157948
Research Fields: Cancer; Immunology
Target: CXCR3
Disease: Allergic responses
Model: Knock-In
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Cohen et al. 2013. PLoS Pathog. 9(10):e1003706. PMID: 24130498.

Oghumu et al. 2013. J Immunol. 190(5):2229-40. PMID: 23338236.

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