The Bmx-Cre-ERT2 mouse is an ideal tool in the study of gene function in angiogenesis, atherosclerosis and neovascularisation.
| Inventor | Institute |
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| Ralf H. Adams | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151454 |
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| Product description: | The Bmx-Cre-ERT2 mouse is an ideal tool in the study of gene function in angiogenesis, atherosclerosis and neovascularisation. |
| Conditional: | Yes |
| Conditional description: | Conditional Cre-ERT2 expression under Bmx promoter enabling tissue-specific recombinase in arterial endothelial cells; inducible Cre activity by treatment with hormone (tamoxifen) enabling inducible translocation of Cre-ERT2 to nucleus. |
| Genetic background: | A Bmx-Cre-ERT2 transgene vector, containing a genomic VECad promoter fragment fused to a Cre-ERT2 cDNA, was injected into fertilised embryos (C57BL/6 or FVB/N). Founder lines were back-crossed to establish mice heterozygous for the Bmx-Cre-ERT2 transgene. |
| Production details: | A Bmx-Cre-ERT2 transgene vector, containing a genomic VECad promoter fragment fused to a Cre-ERT2 cDNA, was injected into fertilised embryos (C57BL/6 or FVB/N). Founder lines were back-crossed to establish mice heterozygous for the Bmx-Cre-ERT2 transgene. |
| Cat. #: | 151454 |
|---|---|
| Research Fields: | Developmental biology; Genetics; Immunology; Neurobiology; Tissue-specific biology |
| Target: | BMX, CreERT2 |
| Disease: | Cancer |
| Model: | Conditional KO |
| Zygosity: | Heterozygous |
| Shipping conditions: | Embryo/Spermatoza- Dry Ice |
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| References: |
Murphy et al. 2014. Proc Natl Acad Sci U S A. 111(50):18007-12. PMID: 25468970. Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels. Noels et al. 2014. Arterioscler Thromb Vasc Biol. 34(6):1209-20. PMID: 24723559. Schober et al. 2014. Nat Med. 20(4):368-76. PMID: 24584117. Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-pro… |
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